Elaboration of measures aimed at eliminating BLAD-carrier bulls of Ukrainian black-and-white dairy breed cattle
Keywords:
breed, sire, BLAD, allele, genotypeAbstract
The purpose of the study is to estimate the frequency of bulls of the Ukrainian black-and-white dairy breed that are carriers of the recessive allele of the CD18 locus of cattle and to propose measures to reduce its prevalence. The analysis showed a high frequency of the recessive BLAD (BL) in the Ukrainian bulls belonging to Holstein-derived breeds. Lack of control over the spread of this hereditary congenital disorder has led to the uncontrolled use of BLAD carrier bulls. The the bovine CD 18 locus was conducted on 30 bulls of the Ukrainian Black-and-White dairy breed. It was found that 90% of bulls had the unaffected genotype at the CD18 locus (TL/TL), and 10% were heterozygotes (TL/BL) and could potentially spread the disease. As a result of studying the pedigrees and genotypes of animals, the authors propose measures to control the spread of the BLAD mutation in the dairy herds of Ukrainian Black-and-White dairy breed.
References
Abraham, V. et al. (2019). Carrier frequency of autosomal recessive disorders (BC, BLAD, FXID and CVM) in Holstein cows in Jalisco, Mexico1. Pesquisa Veterinária Brasileira, 39 (7), 481-484. https://doi.org/10.1590/1678-5150-PVB-6202
Akyüz, B. & Ertuğrul, O. (2006). Detection of Bovine Leukocyte Adhesion Deficiency (BLAD) in Turkish native and Holstein cattle. Acta Veterinaria Hungarica, 54 (2), 173–178. https://doi.org/10.1556/AVet.54.2006.2.4
Bashchenko M.I. et al. (2011). Determination of genetic abnormalities in cattle. Chubynske: Guidelines.
Biriukova, O. (2003). Genealogical analysis of BLAD gene prevalence in the population. Bulletin of Agricultural Science, 8, 68-70.
Burkat, V.P., Konovalov V.S. & Biriukova O.D. (2006) Prospects for victorian development of the genetics of biotechnology in practical breeding of tvarin. Chubynske.
Burkat, V.P. et al. (2005). Recommendations for genetic control of BLAD mutations prevalence in cattle. Chubynske.
Czarnik, U. et al. (2007). Effectiveness of a program aimed at the elimination of BLAD-carrier bulls from Polish Holstein-Friesian cattle. Journal of Applied Genetics, 48, 375–377. https://doi.org/10.1007/BF03195235
Emine, S. et al. (2013). Identification of bovine leukocyte adhesion deficiency (BLAD) and bovine citrullinaemia (BC) alleles in Holstein cows reared in Antalya region. Journal of Applied Animal Research, 41 (1), 56-60. https://doi.org/10.1080/09712119.2012.738221
Gozdek, M. et al. (2020). Report on the incidence of hereditary disorders (BLAD, DUMPS) in the Polish population of Holstein-Friesian cattle, Acta Sci. Pol. Zootechnica, 19 (3), 15–22. https://doi.org/10.21005/asp.2020.19.3.02
Ladyka V. et al. (2019). Molecular-Genetic Analysis of Cows Genetic Structure and Determination of Genealogical Relatedness Level of Bulls of Modern Dairy Breeds. Advances in Animal and Veterinary Sciences. 7 (5), 405-411. https://doi.org/10.17582/journal.aavs/2019/7.5.405.411
Luciana, A. et al. (2000). PCR screening and allele frequency estimation of bovine leukocyte adhesion deficiency in Holstein and Gir cattle in Brazil, Genetics and Molecular Biology, 23(4), 831-834. https://doi.org/10.1590/S1415-47572000000400021
Meydan, H. Yildiz, M. & Agerholm J. (2010). Screening for bovine leukocyte adhesion deficiency, deficiency of uridine monophosphate synthase, complex vertebral malformation, bovine citrullinaemia, and factor XI deficiency in Holstein cows reared in Turkey. Acta Veterinaria Scandinavica, 56, 52-56. https://doi.org/10.1186/1751-0147-52-56
Nasreen, F. et al. (2009). Detection and screening of bovine leukocyte adhesion deficiency in Pakistan using molecular methods. Hereditas, 146, 74-78. https://doi.org/10.1111/j.1601-5223.2009.02093.x
Polupan, Yu.P. et al. (2019). Recommendations for the selection of bulls for breeding stock in dairy farming, Chubynske.
Skliarenko, Yu.I. & Bratushka, P.V. (2012). Further prospects of the selection of Sumy intra-breed type of Ukrainian Black-and-White dairy breed. Breeding and genetics of animals, 46, 109-112.
Sklyarenko, Y. et al. (2018). Lebedyn cattle breed genetic pool genesis and new types and breeds developed on its base. Bulgarian Journal of Agricultural Science, 24 (6), 1114–1122
Vinnychuk, D.T. & Pabat, V.O. (1996). Substantiation of the selection system in commercial herds of Holsteinized dairy cattle, Kyiv.
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Copyright (c) 2023 Yuriy Skliarenko, Yuliia Pavlenko, Iryna Levchenko, Volodymyr Ostapenko, Liudmyla Bula, Tatyana Chernyavska, Lyubov Ladyka, Liudmyla Baidak
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